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阿尔茨海默症(Alzheimer’s disease,AD)是以进行性认知功能障碍和行为损害为特征的中枢神经系统退行性病变,是最常见的老年痴呆病类型.现有治疗阿尔茨海默症的临床常用药物有多奈哌齐、利斯的明、他克林、加兰他敏等,但患者服药后会产生较强的毒副作用.目前已发现多种中药有效成分(如苷类、黄酮类、生物碱类等)对AD有较好的治疗作用且毒副作用小.结合国内外已有的对AD有治疗作用的中药有效成分的相关报道,综述了不同类型中药有效成分对AD的治疗作用,以期为治疗AD的中药类药物开发提供一定的参考.
Abstract：Alzheimer's disease(AD)is a central nervous system degenerative disease characterized by progressive cognitive impairment and behavioral impairment.It is the most common type of Alzheimer's disease.The current commonly used drugs for Alzheimer's disease are Donepezil,Rivastigmine,Klein,and Franklin,but patients may have strong toxic and side effects after taking medicine.Many effective ingredients of Chinese medicine(such as glycosides,flavonoids,alkaloids,etc.)have been found to have good therapeutic effects on AD and have little toxic side effects.Based on the related literature on effective ingredients of AD,which has been reported in China and abroad,this article reviews the therapeutic effects of different effective ingredients of traditional Chinese medicine on AD to provide some references for the development of traditional Chinese medicine drugs for the treatment of AD.
[1]李成冲.石菖蒲活性成分β-细辛醚抗老年痴呆模型大鼠海马细胞凋亡作用及机制[D].佳木斯:佳木斯大学,2010.
[2]刘晏伊,陈超,李志鹏,等.Tau蛋白的磷酸化对阿尔兹海默症影响的相关研究[J].中国老年保健医学,2016,14(5):8-11.
[3]叶民.阿尔茨海默病病因及发病机制研究进展[J].实用老年医学,2017(5):402-406.
[4]彭彬.人参皂苷Rg1延缓神经干细胞衰老作用及机理研究[D].重庆:重庆医科大学,2011.
[5]吴蕾,陈云波,王奇,等.人参皂苷对Aβ25-35蛋白诱导的老年性痴呆体外模型NG108-15神经元细胞凋亡的抑制作用[J].广州中医药大学学报,2007,24(2):126-131.
[6]刘慧琳.人参皂甙Rb1对血管性痴呆大鼠认知功能障碍的防治作用[D].西安:第四军医大学,2013.
[7]周超群,周珮.人参皂苷Rd的研究进展[J].中草药,2009,40(5):832-836.
[8]朱璋佩,王建,黄立华,等.远志皂苷类成分及其在动物体内代谢过程的研究进展[J].中药与临床,2016,7(4):61-65.
[9]黄炎,陈逸青,陈勤,等.远志皂苷对Aβ1-40诱导痴呆大鼠海马神经细胞线粒体的保护作用[J].中药药理与临床,2015(1):93-97.
[10]马洪伟,付文亮,钟美蓉,等.远志药理活性研究进展[J].承德医学院学报,2010,27(2):196-198.
[11]郭新明.远志皂苷对快速老化小鼠学习记忆功能及脑组织乙酰胆碱酯酶水平的影响[J].中华实用诊断与治疗杂志,2016,30(6):578-580.
[12]张静娴,崔艳梅.中药何首乌的化学成分研究[J].中国中药杂志,2016,41(17):3252-3255.
[13]吕丽爽.何首乌中二苯乙烯苷的研究进展[J].食品科学,2006,27(10):608-612.
[14]刘宁.二苯乙烯苷对阿尔茨海默病模型小鼠学习记忆能力及脑组织中APP异常裂解相关蛋白表达的影响[D].百色:右江民族医学院,2017.
[15]朱秀珍,申文伟,龚翠莹,等.异荭草苷体内外抗呼吸道合胞病毒活性研究[J].中山大学学报(医学科学版),2015,36(3):352-359.
[16]马祥,晏日安,逯与运.脂肪酶催化竹叶抗氧化物中异荭草苷和异牡荆苷酰化[J].食品科学,2013,34(16):265-269.
[17]LIANG Zhibin,ZHANG Bei,SU Weiwen,et al.Cglycosylflavones alleviate Tau phosphorylation and amyloid neurotoxicity through GSK3βinhibition[J].ACS Chemical Neuroscience,2016,7(7):912-923.
[18]NI Yang,LI Lin,ZHANG Weiyang,et al.Discovery and LC-MS characterization of new crocins in gardeniae fructus and their neuroprotective potential[J].Journal of Agricultural&Food Chemistry,2017,65(14):2936-2946.
[19]黄芳,蒙义文.活性多糖的研究进展[J].天然产物研究与开发,1999(5):90-98.
[20]YU M S,LAI C S,HO Y S,et al.Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity[J].International Journal of Molecular Medicine,2007,20(2):261-268.
[21]葛建彬,卢红建,宋新建,等.枸杞多糖对小鼠脑缺血再灌注损伤的保护作用及其抑制NF-κB,TNF-α,IL-6和IL-1β表达的机制[J].中国中药杂志,2017,42(2):326-331.
[22]李雪燕,安方玉,李世功,等.当归多糖对老年痴呆小鼠脑组织钙超载及胆碱能神经损伤的影响[J].中医研究,2013,26(3):68-70.
[23]安方玉,刘雪松,张艳霞,等.当归多糖对AD模型小鼠抗衰老作用研究[J].中国药事,2014(11):1223-1226.
[24]袁电杰,张印发,姚春香.灵芝多糖对阿尔茨海默病模型大鼠海马内突触及突触素表达的影响[J].中国实验方剂学杂志,2011,17(3):151-155.
[25]成威,田伟,李友元,等.黄精多糖对APP转基因小鼠海马CA1区突触结构的影响[J].中国实验方剂学杂志,2010,16(10):165-167.
[26]未小明,王爱梅,罗朝辉,等.黄精对AD模型大鼠空间学习记忆及α7nAChR表达的影响[J].神经解剖学杂志,2016,32(3):391-396.
[27]赵雪巍,刘培玉,刘丹,等.黄酮类化合物的构效关系研究进展[J].中草药,2015,46(21):3264-3271.
[28]孙晶,邵胜敏,赵丹,等.大豆异黄酮对AD模型大鼠认知功能及脑内胆碱能系统的影响[J].心脑血管病防治,2010,10(6):421-424.
[29]毕建忠,王萍,王世军,等.大豆异黄酮对Alzheimer病大鼠认知功能及海马NR2B表达的影响[J].临床神经病学杂志,2005,18(6):432-435.
[30]BRACKMAN G,AL QUNTAR A A,ENK C D,et al.Synthesis and evaluation of thiazolidinedione and dioxazaborocane analogues as inhibitors of AI-2quorum sensing in Vibrio harveyi[J].Bioorganic&Medicinal Chemistry,2013,21(3):660-667.
[31]黄雪媚.针对阿尔茨海默病中Aβ42靶点的抗体与天然药物的效应分析[D].长春:吉林大学,2011.
[32]张云莎,杨琳,庞赓,等.银杏内酯和银杏黄酮干预β-淀粉样蛋白跨血脑屏障低氧模型转运的体外研究[J].广东医学,2016,37(16):2389-2392.
[33]WANG Qiuming,YU Xiang,PATAL K,et al.Tanshinones inhibit amyloid aggregation by amyloid-βpeptide,disaggregate amyloid fibrils and protect cultured cells[J].ACS Chemical Neuroscience,2013,4(6):1004-1015.
[34]杨月莹,于淼,季宇彬.石蒜属植物生物碱药理作用的研究[J].哈尔滨商业大学学报(自然科学版),2016,32(2):129-131.
[35]辛利娟.三种传统药用植物化学成分及石蒜生物碱活性研究[D].北京:中央民族大学,2012.
[36]YUAN Shumin,GAO Kai,WANG Dongmei,et al.Evodiamine improves congnitive abilities in SAMP8and APPswe/PS1ΔE9 transgenic mouse models of Alzheimer’s disease[J].Acta Pharmacologica Sinica,2011,32(3):295-302.
[37]王冬梅,马元武,袁树民,等.柚皮苷及其与吴茱萸碱联合用药对APPswe/PSΔE9转基因痴呆模型小鼠学习记忆能力的影响[J].中国实验动物学报,2012,20(2):59-63.
[38]李洁佳.藁本内酯对抗D-半乳糖和过氧化氢致氧化应激损伤的神经保护作用[D].南通:南通大学,2010.
[39]CHENG Liling,CHEN Xinan,WANG Yu,et al.Zligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice[J].Fitoterapia,2011,82(7):1128-1132.
[40]李清春,刁汇玲,蒋淑君,等.银杏内酯对拟老年痴呆模型大鼠学习记忆能力的影响[J].解剖学杂志,2007,30(3):336-339.
[41]赵先,王婧雯,陆杨,等.丹酚酸B药理作用的研究进展[J].西北药学杂志,2015,21(1):107-110.
[42]TANG Minke,ZHANG Juntian.Salvianolic acid B inhibits fibril formation and neurotoxicity of amyloid beta-protein in vitro[J].Acta Pharmacologica Sinica,2001(4):94-98.
[43]QIAO Aimin,WANG Yihai,ZHANG Wanwan,et al.Neuroprotection of brain-targeted bioactive dietary artoindonesianin O(AIO)from mulberry on rat neurons as a novel intervention for Alzheimer’s disease[J].Journal of Agricultural&Food Chemistry,2015,63(14):3687.
[44]ZHOU Hongyu,SHIN E M,GUO Lianyu,et al.Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2expression in RAW 264.7 macrophages via NF-kappa B,JNK and p38MAPK inactivation[J].European Journal of Pharmacology,2008,586(1/2/3):340-349.
[45]MUNROE M E,ARBISER J L,BISHOP G A.Honokiol,a natural plant product,inhibits inflammatory signals and alleviates inflammatory arthritis[J].Journal of Immunology,2007,179(2):753-763.
[46]LIN Y R,CHEN H H,KO C H,et al.Effects of honokiol and magnolol on acute and inflammatory pain models in mice[J].Life Sciences,2007,81(13):1071-1078.
[47]LIOU K T,SHEN Y C,CHEN C F,et al.Honokiol protects rat brain from focal cerebral ischemiareperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production[J].Brain Research,2003,992(2):159-166.
[48]LIN Y R,CHEN H H,KO C H,et al.Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage[J].European Journal of Pharmacology,2006,537(1/2/3):64-69.
[49]FUJITA S,TAIRA J.Biphenyl compounds are hydroxyl radical scavengers:their effective inhibition for UV-induced mutation in Salmonella typhimurium TA102[J].Free Radical Biology&Medicine,1994,17(3):273-277.
[50]DIKALOV S,LOSIK T,ARBISER J L.Honokiol is apotent scavenger of superoxide and peroxyl radicals[J].Biochemical Pharmacology,2008,76(5):589-596.
[51]KURIBARA H,STAVINOHA W B,MARUYAMA Y.Behavioural pharmacological characteristics of honokiol,an anxiolytic agent present in extracts of Magnolia bark,evaluated by an elevated plus-maze test in mice[J].Journal of Pharmacy&Pharmacology,1998,50(7):819-826.
[52]WATANABE K,WATANABE H,GOTO Y,et al.Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis:central depressant effects[J].Planta Medica,1983,49(2):103-108.
[53]LEE Y K,CHOI I S,BAN J O,et al.4-O-methylhonokiol attenuatedβ-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38MAP kinase[J].Journal of Nutritional Biochemistry,2011,22(5):476-486.
[54]张美璇.石菖蒲抗老年痴呆活性部位的确定及其初步物质基础研究[D].上海:中国医药工业研究总院,2016.
[55]LI Xiaolong,ZHAO Xu,XU Xuan,et al.Schisantherin A recovers Aβ-induced neurodegeneration with cognitive decline in mice[J].Physiology&Behavior,2014,132(4):10-16.
[56]LUO Qi,YANG Zhuliang,YAN Yongming,et al.Ganotheaecolin A,a neurotrophic conjugated ergosterol with a naphtho[1,8-ef]azulene scaffold from Ganoderma theaecolum[J].Organic Letters,2017,19(3):718-721.
[57]NAVABI S P,SARKAKI A,MANSOURI E,et al.The effects of betulinic acid on neurobehavioral activity,electrophysiology and histological changes in an animal model of the Alzheimer’s disease[J].Behavioural Brain Research,2017,337:99-106.
[58]MANIGANDAN V,RAMANATHAN T.In silico docking of mangrove derived ligands against Alzheimer’s receptor proteins[J].Current Research in Neuroscience,2014,4(1):18-24.
基本信息:
中图分类号:R285
引用信息:
[1]任抒婷,王蕾,吴煜然,等.治疗阿尔茨海默症的中药有效成分研究进展[J].淮海工学院学报(自然科学版),2018,27(03):28-33.
基金信息:
江苏省自然科学基金项目(BK20151281);; 国家海洋公益性行业科研专项(201505023)
2018-09-15
2018-09-15